Levodopa

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Levodoparaw

Leguminosae mucuna adans is a kind of annual herbaceous climber plant, cylindrical stem, with 2-10m length of vine, multi-branches, ternate compound leaf, moment round oval of leaflet, botryose inflorescence, papilionaceous corolla, almost white or purple It is mainly located in southern, south-west, Jiangxi, Hunan, Guangxi provinces and so on The whole body of Civet beans is valuable, its shell, leaf and bean contains abundant crude fat and crude protein, as a quite good pig mash Beans are the main raw materials of Levodopa

LevodopaProducts

English name: Levodopa 
Synonym: 3-(3,4-Dihydroxyphenyl)-L-alanine; L-3-(3,4-Dihydroxyphenyl)alanine; L-DOPA
Chemical name: (2S)-2-Amino-3-(3,4-dihydroxyphenyl) propanoic acid
CAS NO.:59-92-7
M.F.&M.W.:C9H11NO4     197.19
Physical property: Colorless to white, odorless tasteless crystalline or crystal powder, needle crystalline(water), M.P.: 276-278℃ [α]12D-13.1℃ (C=5.12,1N hydrochloric acid), freely soluble in dilute hydrochloric acid and methanoic acid, soluble in water (65mg/44ml), practically insoluble in ethanol, benzene, chloroform and acetic ether. UVλ0.001NHCl max nm(logε):220.5(3.97), 280(3.42)[1]。IRνmax cm-1: 3450, 3230, 3030, 2630, 1670, 1590, 1540, 1470, 1410, 1350, 1280, 1250, 1120, 1060, 980, 940, 920, 860, 820, 780, 730, 670[2].
Plant source: Vicia faba L. Mucuna cochin-chinensisi (lour) A. cheval. Seed[3] M.semporvirens hemsl. Seed [4] M. birdwoodiana tuteh. Seed[5] stizolobium caprtatum (sweet) O. kuntze. 
Indications: Levodopa is one of the precursors which synthesis in vivo to noradrenaline and dopamine, can increasing the level of dopamine in brain tissue. Parkinson’s disease is caused by dopamine deficiency in brain tissue, for this reason, levodopa can be used for the treatment of Pakinson’s disease, relieving symptoms (not directly application for exogenous dopamine). Also has effect on similar poisoning symptoms caused by manganese and cobalt, magnificent effect on hepatic coma caused by acute hepatic failure. Toxicity: LD oral administration (mg/kg): mice at 3650, rat at more than 40000, rabbit at 609.
 
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